The mid game of Yahtzee dice game depends mainly on your already filled score cards. You should always have the upper section in mind when deciding your best course of action.

If you have had large straight filled, play aggressively with x-of-kinds to to concentrate with the four of a kind.

If you have 4 of a kind filled, you should then focus on the large straight.

If neither of the sections are filled, refer to the opening strategy to help you with the best way to score. You generally should be more opportunistic and look for any potentials to score a large straight.